Preleukemia: one name, many meanings
Identifieur interne : 000279 ( Main/Exploration ); précédent : 000278; suivant : 000280Preleukemia: one name, many meanings
Auteurs : H P Koeffler [États-Unis, Singapour] ; G. Leong [Singapour]Source :
- Leukemia [ 0887-6924 ] ; 2017.
Abstract
Definition of preleukemia has evolved. It was first used to describe the myelodysplastic syndrome (MDS) with a propensity to progress to acute myeloid leukemia (AML). Individuals with germline mutations of either
Url:
DOI: 10.1038/leu.2016.364
PubMed: 27899806
PubMed Central: 5339433
Affiliations:
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<series><title level="j">Leukemia</title>
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<front><div type="abstract" xml:lang="en"><p>Definition of preleukemia has evolved. It was first used to describe the myelodysplastic syndrome (MDS) with a propensity to progress to acute myeloid leukemia (AML). Individuals with germline mutations of either <italic>RUNX1</italic>
, <italic>CEBPA</italic>
, or <italic>GATA2</italic>
can also be called as preleukemic because they have a markedly increased incidence of evolution into AML. Also, alkylating chemotherapy or radiation can cause MDS/preleukemia, which nearly always progress to AML. More recently, investigators noted that AML patients who achieved complete morphological remission after chemotherapy often have clonal hematopoiesis predominantly marked by either <italic>DNMT3A</italic>
, <italic>TET2</italic>
or <italic>IDH1/2</italic>
mutations, which were also present at diagnosis of AML. This preleukemic clone represents involvement of an early hematopoietic stem cells, which is resistant to standard therapy. The same clonal hematopoietic mutations have been identified in older ‘normal' individuals who have a modest increased risk of developing frank AML. These individuals have occasionally been said, probably inappropriately, to have a preleukemia clone. Our evolving understanding of the term preleukemia has occurred by advancing technology including studies of X chromosome inactivation, cytogenetics and more recently deep nucleotide sequencing.</p>
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